Cucumber mosaic virus with antibodies
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Cucumber mosaic virus with antibodies
Cucumber mosaic virus (CMV) with antibody fragments attached, computer model. This image was created using molecular modelling software and data from cryo-electron microscopy. The image shows the outer protein shell of the virus (red), known as the capsid. It is covered with antibody fragments (pink, light to dark blue), known as Fab (antigen binding fragments). CMV is transmitted by aphids and infects a wide number of crop plants, causing stunted growth, wilting, mottling and poor fruit yield. Cryo-electron microscopy uses multiple angled beams of electrons to image specimens kept at minus 150 degrees Celsius. The resulting slices of data are reconstructed into 3-D models on computer
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Media ID 6434935
© THOMAS SMITH/DANFORTH CENTER/SCIENCE PHOTO LIBRARY
3 D Visualisation 3 D Visualization Antibody Capsid Computer Graphic Computer Rendering Cryo Electron Microscope Cryo Em Cryoelectron Microscopy Immune Response Immunology Macromolecular Macromolecule Modelling Molecular Imaging Particle Plant Disease Plant Pathogen Plant Virus Protein Shell Reconstruction Shape Structural Biology Surface Viral Shell Virion Virology Micro Biology Microbiological Molecular Model Molecular Structure Pathogen Protein Virus
EDITORS COMMENTS
This image showcases the intricate structure of the Cucumber mosaic virus (CMV) with antibody fragments attached, providing a glimpse into the world of molecular biology. Created using advanced molecular modelling software and data obtained from cryo-electron microscopy, this computer-generated illustration reveals the outer protein shell of CMV, known as the capsid, in striking red hues. The capsid is adorned with antibody fragments in varying shades of pink and light to dark blue. CMV is a notorious plant pathogen transmitted by aphids that wreaks havoc on numerous crop plants. Its detrimental effects include stunted growth, wilting, mottling, and diminished fruit yield. Understanding its complex structure through techniques like cryo-electron microscopy allows scientists to unravel its mechanisms and devise strategies for combating this destructive virus. Cryo-electron microscopy involves freezing specimens at an astonishingly low temperature of minus 150 degrees Celsius while capturing multiple angled beams of electrons to generate high-resolution images. These images are then reconstructed into detailed 3D models using cutting-edge computational tools. The fusion between artistry and science showcased in this image highlights the importance of structural biology in unravelling the mysteries behind pathogens like CMV. It serves as a testament to our ever-evolving understanding of viruses and our relentless pursuit towards developing effective treatments against them.
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