Transcription factor complexed with DNA
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Transcription factor complexed with DNA
Transcription factor complexed with DNA. Computer model showing sterol regulatory element binding transcription factor 1 (SREBF1, purple and pink) bound to a section of DNA (deoxyribonucleic acid, orange and green). Transcription factors are proteins that bind to specific sequences of DNA and control the transcription (transfer) of genetic information from DNA to RNA (ribonucleic acid). SREBF1 is involved in the synthesis of sterols (such as cholesterol). It travels to the nucleus and activates transcription by binding to sterol regulatory element-1 (SRE1). The presence of sterols inhibits the formation of SREBF1 and the mature nuclear form is rapidly broken down, thereby reducing transcription
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6303749
© LAGUNA DESIGN/SCIENCE PHOTO LIBRARY
Biosynthesis Bound Cholesterol Complex Complexed Genetic Nucleic Acid Proteins Proteomics Regulate Regulation Space Fill Space Filled Transcription Transcription Factor Bio Chemistry Biochemical Deoxyribonucleic Acid Genetics Molecular Model Protein Transcribe
EDITORS COMMENTS
This print showcases a computer-generated model of a transcription factor complexed with DNA. The image depicts the sterol regulatory element binding transcription factor 1 (SREBF1) in vibrant shades of purple and pink, intricately bound to a section of DNA represented by orange and green strands. Transcription factors are essential proteins that possess the remarkable ability to bind to specific sequences of DNA, thereby controlling the transfer of genetic information from DNA to RNA. SREBF1, prominently featured in this artwork, plays a crucial role in synthesizing sterols like cholesterol within living organisms. Upon reaching the nucleus, SREBF1 activates transcription by binding itself to sterol regulatory element-1 (SRE1). Interestingly, when there is an abundance of sterols present, their presence inhibits the formation of SREBF1. Consequently, the mature nuclear form rapidly breaks down as part of a feedback mechanism aimed at reducing transcription. This visually stunning illustration beautifully captures various aspects related to biology and biochemistry - from molecular models and space fill structures to nucleic acids and protein regulation. It offers us an intriguing glimpse into the intricate world where genetics meet biochemical processes. This mesmerizing artwork serves as a testament to Science Photo Library's dedication towards showcasing cutting-edge scientific visuals while exploring complex concepts such as gene expression regulation through transcription factors like SREBF1.
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