Gauchers disease, light micrograph
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Gauchers disease, light micrograph
Gauchers disease. Light micrograph of a section through the spleen of a patient with Gauchers disease. This is an inherited metabolic disorder in which a fatty substance called glucocerebroside accumulates in the spleen, lungs, liver and bone marrow, and sometimes the brain. This is due to an absence of the enzyme glucocerebrosidase (GC). The disease appears in childhood, and some forms are fatal in the first few years. Other forms cause enlargement of the affected organs, weak and painful bones and anaemia. Some forms also cause severe nervous system damage. There is no cure, but enzyme replacement therapy using GC can relieve the symptoms
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9207537
© CNRI/SCIENCE PHOTO LIBRARY
Familial Genetic Histopathological Histopathology Inherited Metabolic Spleen Splenic Stain Stained Abnormal Condition Disorder Light Micrograph Light Microscope Section Sectioned Unhealthy
EDITORS COMMENTS
This print showcases the intricate details of Gaucher's disease, a rare inherited metabolic disorder. The light micrograph captures a section through the spleen of a patient affected by this condition. Gaucher's disease is characterized by the abnormal accumulation of glucocerebroside, a fatty substance, in various organs such as the spleen, lungs, liver, bone marrow, and sometimes even the brain. The absence of an essential enzyme called glucocerebrosidase (GC) leads to this accumulation and subsequent health complications. Typically appearing in childhood, some forms of Gaucher's disease can be fatal within the first few years. Other variations manifest with enlarged organs, weak and painful bones, anemia, and severe damage to the nervous system. Unfortunately, there is currently no cure for Gaucher's disease; however, there are treatment options available to alleviate symptoms. Enzyme replacement therapy utilizing GC has shown promise in managing this debilitating condition. Through this visually striking image captured under a light microscope using staining techniques commonly employed in histopathology studies within healthcare settings worldwide; we gain insight into the complex nature of this genetic disorder known as Gaucher's disease or sphingolipidosis - shedding light on its pathophysiology and contributing towards ongoing research efforts aimed at improving patients' lives.
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