General Anaesthesia Collection

Anaesthetic inhibiting an ion channel C015 / 6718
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Re-enactment of first anaesthesia, 1850
Re-enactment of first anaesthesia. Group of surgeons and a patient re-enacting the first operation that was carried out under general anaesthesia

Ketamine drug binding to ion channel, molecular model. Several molecules of the drug ketamine binding to a pentameric ligand-gated ion channel (pLGIC)

Anaesthetic inhibiting an ion channel C015 / 6723
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Anaesthetic inhibiting an ion channel C015 / 6722
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Anaesthetic inhibiting an ion channel C015 / 6720
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey)

Anaesthetic inhibiting an ion channel C015 / 6721
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Anaesthetic inhibiting an ion channel C015 / 6719
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

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Step back in time to the 1850s, as we revisit the pivotal moment when anesthesia transformed surgery from a painful ordeal into a manageable medical procedure. Fast forward to modern times, and the intricacies of this life-changing discovery unfold at the molecular level. Witness the anesthetic's interaction with ion channel C015/6718, as it inhibits the normal flow of ions, inducing a state of unconsciousness. Delve deeper into the mechanism, observing how ketamine, a commonly used anesthetic, binds to ion channels C015/6720, C015/6721, C015/6722, and C015/6723, altering their function and ultimately, providing relief from pain and sensation during surgery. This captivating dance between anesthetics and ion channels continues to unfold, offering endless possibilities for advancing our understanding of anesthesia and improving patient care.